JMY antibody (AA 708-848)

Catalog No. ABIN7157162

This Rabbit Polyclonal antibody specifically detects JMY in ELISA, IHC and IF. It exhibits reactivity toward Human.

Quick Overview for JMY antibody (AA 708-848) (ABIN7157162)

Target: JMY (Junction Mediating and Regulatory Protein, P53 Cofactor (JMY))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This JMY antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-JMY Antibody

Binding Specificity: AA 708-848

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Junction-mediating and -regulatory protein (708-848AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for JMY

Target: JMY (Junction Mediating and Regulatory Protein, P53 Cofactor (JMY))

Alternative Name: JMY

Background:

Background: Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location (By similarity).

Aliases: FLJ37870 antibody, Jmy antibody, JMY protein antibody, JMY_HUMAN antibody, junction mediating and regulatory protein antibody, Junction mediating and regulatory protein p53 cofactor antibody, Junction-mediating and -regulatory protein antibody, MGC163496 antibody, OTTHUMP00000161976 antibody, WAS protein homology region 2 domain containing 1-like 3 antibody, WHDC1L3 antibody

UniProt: Q8N9B5

Pathways: Regulation of Actin Filament Polymerization