PKMYT1 antibody (AA 900-1101)

Catalog No. ABIN7159368

The Rabbit Polyclonal anti-PKMYT1 antibody has been validated for ELISA and IHC. It is suitable to detect PKMYT1 in samples from Human.

Quick Overview for PKMYT1 antibody (AA 900-1101) (ABIN7159368)

Target: PKMYT1 (Protein Kinase, Membrane Associated tyrosine/threonine 1 (PKMYT1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PKMYT1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Product Details anti-PKMYT1 Antibody

Binding Specificity: AA 900-1101

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase protein (900-1101AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PKMYT1

Target: PKMYT1 (Protein Kinase, Membrane Associated tyrosine/threonine 1 (PKMYT1))

Alternative Name: PKMYT1

Background:

Background: Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on \'Thr-14\'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on \'Tyr-15\' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.

Aliases: cdc2 inhibitory kinase antibody, DKFZp547K1610 antibody, FLJ20093 antibody, Membrane associated tyrosine and threonine specific cdc2 inhibitory kinase antibody, Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase antibody, MYT1 antibody, Myt1 kinase antibody, PKMYT 1 antibody, Pkmyt1 antibody, PMYT1_HUMAN antibody, PPP1R126 antibody, Protein kinase membrane associated tyrosine/threonine 1 antibody, Protein kinase Myt1 antibody, Protein phosphatase 1 regulatory subunit 126 antibody

UniProt: Q99640

Pathways: Mitotic G1-G1/S Phases, M Phase