H13 antibody (AA 336-377) (Biotin)

Catalog No. ABIN7159823

This Rabbit Polyclonal antibody specifically detects H13 in ELISA. It exhibits reactivity toward Human.

Quick Overview for H13 antibody (AA 336-377) (Biotin) (ABIN7159823)

Target: H13 (Histocompatibility 13 (H13))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This H13 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-H13 Antibody (Biotin)

Binding Specificity: AA 336-377

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Minor histocompatibility antigen H13 protein (336-377AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for H13

Target: H13 (Histocompatibility 13 (H13))

Alternative Name: HM13

Background:

Background: Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides (PubMed:11714810). May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein (PubMed:12145199). Involved in the intramembrane cleavage of the integral membrane protein PSEN1 (PubMed:12077416, PubMed:11714810, PubMed:14741365). Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139-dependent manner (PubMed:25239945). May play a role in graft rejection (By similarity).

Aliases: dJ324O17.1 antibody, H13 antibody, hIMP1 antibody, Histocompatibility (minor) 13 antibody, HM13 antibody, HM13_HUMAN antibody, IMP-1 antibody, IMP1 antibody, IMPAS antibody, IMPAS-1 antibody, Intramembrane protease 1 antibody, Intramembrane protease antibody, Minor histocompatibility antigen 13 antibody, Minor histocompatibility antigen H13 antibody, MSTP086 antibody, OTTHUMP00000030527 antibody, OTTHUMP00000030528 antibody, OTTHUMP00000030530 antibody, OTTHUMP00000214528 antibody, Presenilin-like protein 3 antibody, PSENL3 antibody, PSL3 antibody, Signal peptide peptidase antibody, Signal peptide peptidase beta antibody, SPP antibody

UniProt: Q8TCT9