NPC1 antibody (AA 23-269) (Biotin)

Catalog No. ABIN7161728

This Rabbit Polyclonal antibody specifically detects NPC1 in ELISA. It exhibits reactivity toward Human.

Quick Overview for NPC1 antibody (AA 23-269) (Biotin) (ABIN7161728)

Target: NPC1 (Niemann-Pick Disease, Type C1 (NPC1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NPC1 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-NPC1 Antibody (Biotin)

Binding Specificity: AA 23-269

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human NPC intracellular cholesterol transporter 1 protein (23-269AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for NPC1

Target: NPC1 (Niemann-Pick Disease, Type C1 (NPC1))

Alternative Name: NPC1

Background:

Background: Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular \\\'tag team duo\\\' (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pocket of the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket and is exported from the limiting membrane of late endosomes/ lysosomes to the ER and plasma membrane by an unknown mechanism. Binds oxysterol with higher affinity than cholesterol. May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals.

Aliases: Niemann Pick C1 protein precursor antibody, Niemann Pick disease, type C1 antibody, Niemann-Pick C1 protein antibody, NPC antibody, NPC1 antibody, NPC1_HUMAN antibody

UniProt: O15118