PIN1 antibody (AA 1-163) (Biotin)

Catalog No. ABIN7162852

This anti-PIN1 antibody is a Rabbit Polyclonal antibody detecting PIN1 in ELISA. Suitable for Human.

Quick Overview for PIN1 antibody (AA 1-163) (Biotin) (ABIN7162852)

Target: PIN1 (Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PIN1 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-PIN1 Antibody (Biotin)

Binding Specificity: AA 1-163

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 protein (1-163AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PIN1

Target: PIN1 (Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1))

Alternative Name: PIN1

Background:

Background: Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs. By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes (PubMed:21497122, PubMed:22033920, PubMed:23623683). Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK (PubMed:16644721). Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation (PubMed:15664191). Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner (PubMed:17828269). Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN (PubMed:22608923). May facilitate the ubiquitination and proteasomal degradation of RBBP8/CtIP through CUL3/KLHL15 E3 ubiquitin-protein ligase complex, hence favors DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:23623683, PubMed:27561354).

Aliases: DOD antibody, DODO, Drosophila, homolog of antibody, FLJ40239 antibody, FLJ77628 antibody, MGC10717 antibody, NIMA interacting 1 antibody, Peptidyl prolyl cis trans isomerase NIMA interacting 1 antibody, Peptidyl prolyl cis/trans isomerase NIMA interacting antibody, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 antibody, Peptidyl-prolyl cis-trans isomerase pin1 antibody, Peptidylprolyl cis/trans isomerase NIMA interacting 1 antibody, Pin 1 antibody, Pin1 antibody, PIN1_HUMAN antibody, PPIase Pin1 antibody, Prolyl isomerase antibody, Protein (peptidylprolyl cis/trans isomerase) NIMA interacting 1 antibody, Protein NIMA interacting 1 antibody, Rotamase Pin1 antibody, UBL 5 antibody, UBL5 antibody

UniProt: Q13526