PIK3C3 antibody (Catalytic Subunit) (Biotin)

Catalog No. ABIN7163160

The Rabbit Polyclonal anti-PIK3C3 antibody has been validated for ELISA. It is suitable to detect PIK3C3 in samples from Human.

Quick Overview for PIK3C3 antibody (Catalytic Subunit) (Biotin) (ABIN7163160)

Target: PIK3C3 (Phosphoinositide-3-Kinase, Class 3 (PIK3C3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PIK3C3 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-PIK3C3 Antibody (Biotin)

Binding Specificity: AA 700-850, Catalytic Subunit

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Phosphatidylinositol 3-kinase catalytic subunit type 3 protein (700-850AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PIK3C3

Target: PIK3C3 (Phosphoinositide-3-Kinase, Class 3 (PIK3C3))

Alternative Name: PIK3C3

Background:

Background: Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate, different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530). Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for transport from early to late endosomes (By similarity).

Aliases: hVps34 antibody, MGC61518 antibody, Phosphatidylinositol 3 kinase catalytic subunit type 3 antibody, Phosphatidylinositol 3 kinase class 3 antibody, Phosphatidylinositol 3 kinase p100 subunit antibody, Phosphatidylinositol 3-kinase catalytic subunit type 3 antibody, Phosphatidylinositol 3-kinase p100 subunit antibody, Phosphoinositide 3 kinase class 3 antibody, Phosphoinositide-3-kinase class 3 antibody, PI3 kinase type 3 antibody, PI3-kinase type 3 antibody, PI3K type 3 antibody, Pik3c3 antibody, PK3C3_HUMAN antibody, PtdIns 3 kinase type 3 antibody, PtdIns-3-kinase type 3 antibody, Vps 34 antibody, Vps34 antibody

UniProt: Q8NEB9

Pathways: AMPK Signaling, Activation of Innate immune Response, Inositol Metabolic Process, Toll-Like Receptors Cascades, Autophagy