PARG antibody (AA 1-348) (Biotin)

Catalog No. ABIN7163766

The Rabbit Polyclonal anti-PARG antibody has been validated for ELISA. It is suitable to detect PARG in samples from Human.

Quick Overview for PARG antibody (AA 1-348) (Biotin) (ABIN7163766)

Target: PARG

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PARG antibody is conjugated to Biotin

Application: ELISA

Product Details anti-PARG Antibody (Biotin)

Binding Specificity: AA 1-348

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Poly(ADP-ribose) glycohydrolase protein (1-348AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PARG

Target: PARG

Alternative Name: PARG

Background:

Background: Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase (PubMed:23102699). PARG acts both as an endo- and exoglycosidase, releasing PAR of different length as well as ADP-ribose monomers (PubMed:23102699). Required for retinoid acid-dependent gene transactivation, probably by dePARsylating histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (PubMed:23102699). Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257).

Aliases: ADP riboseglycohydrolase antibody, Mitochondrial poly(ADP ribose) glycohydrolase antibody, Parg antibody, PARG_HUMAN antibody, PARG99 antibody, Poly antibody, poly (ADP ribose) glycohydrolase antibody, poly(ADP-ribose) glycohydrolase 60 kDa isoform antibody, Poly(ADP-ribose) glycohydrolase antibody

UniProt: Q86W56