S1A12 (AA 1-92) antibody

Catalog No. ABIN7166042

Product Details

Target: S1A12

Binding Specificity: AA 1-92

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: ELISA

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Protein S100-A12 protein (1-92AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details

Target: S1A12

Background:

Background: S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases, MMP2, MMP3 and MMP9 by chelating Zn2+ from their active sites. Possesses filariacidal and filariastatic activity. Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus.

Aliases: CAAF1 antibody, CAGC antibody, Calcitermin antibody, Calcium-binding protein in amniotic fluid 1 antibody, Calgranulin C antibody, Calgranulin-C antibody, Calgranulin-related protein antibody, CGRP antibody, EN RAGE antibody, EN-RAGE antibody, ENRAGE antibody, Extracellular newly identified RAGE-binding protein antibody, migration inhibitory factor-related protein 6 antibody, MRP6 antibody, Neutrophil S100 protein antibody, p6 antibody, Protein S100 A12 antibody, S100 calcium binding protein A12 antibody, S100 calcium-binding protein A12 (calgranulin C) antibody, S100 calcium-binding protein A12 antibody, S100A12 antibody, S10AC_HUMAN antibody

UniProt: P80511