RNF11 antibody (AA 1-154)

Catalog No. ABIN7168238

This Rabbit Polyclonal antibody specifically detects RNF11 in ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for RNF11 antibody (AA 1-154) (ABIN7168238)

Target: RNF11 (Ring Finger Protein 11 (RNF11))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RNF11 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Product Details anti-RNF11 Antibody

Binding Specificity: AA 1-154

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human RING finger protein 11 protein (1-154AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for RNF11

Target: RNF11 (Ring Finger Protein 11 (RNF11))

Alternative Name: RNF11

Background:

Background: Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates \\\'Lys-63\\\' polyubiquitin chains on RIPK1 and catalyzes the formation of \\\'Lys-48\\\'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome.

Aliases: CGI 123 antibody, RING finger protein 11 antibody, RNF11 antibody, RNF11_HUMAN antibody, Sid 1669 antibody, SID1669 antibody

UniProt: Q9Y3C5