PIM2 antibody (AA 1-210) (Biotin)

Catalog No. ABIN7169146

This anti-PIM2 antibody is a Rabbit Polyclonal antibody detecting PIM2 in ELISA. Suitable for Human.

Quick Overview for PIM2 antibody (AA 1-210) (Biotin) (ABIN7169146)

Target: PIM2 (Proto-Oncogene Pim-2 (Serine Threonine Kinase) (PIM2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PIM2 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-PIM2 Antibody (Biotin)

Binding Specificity: AA 1-210

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Serine/threonine-protein kinase pim-2 protein (1-210AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PIM2

Target: PIM2 (Proto-Oncogene Pim-2 (Serine Threonine Kinase) (PIM2))

Alternative Name: PIM2

Background:

Background: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappa-B kinase/NF-kappa-B cascade, this process requires phosphorylation of MAP3K8/COT. Promotes growth factor-independent proliferation by phosphorylation of cell cycle factors such as CDKN1A and CDKN1B. Involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate.

Aliases: OTTHUMP00000025825 antibody, Pim 2 oncogene antibody, Pim 2h antibody, Pim-2h antibody, PIM2 antibody, PIM2 Oncogene antibody, PIM2_HUMAN antibody, Pim2h antibody, Proto Oncogene PIM2 antibody, Proto-oncogene Pim-2 (serine threonine kinase) antibody, Serine/threonine kinase PIM2 antibody, Serine/threonine-protein kinase Pim-2 antibody

UniProt: Q9P1W9