ULK1 antibody (AA 602-715) (HRP)

Catalog No. ABIN7169208

The Rabbit Polyclonal anti-ULK1 antibody has been validated for ELISA. It is suitable to detect ULK1 in samples from Human.

Quick Overview for ULK1 antibody (AA 602-715) (HRP) (ABIN7169208)

Target: ULK1 (Unc-51 Like Kinase 1 (ULK1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ULK1 antibody is conjugated to HRP

Application: ELISA

Product Details anti-ULK1 Antibody (HRP)

Binding Specificity: AA 602-715

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Serine/threonine-protein kinase ULK1 protein (602-715AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ULK1

Target: ULK1 (Unc-51 Like Kinase 1 (ULK1))

Alternative Name: ULK1

Background:

Background: Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR, however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. May also phosphorylate SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165).

Aliases: ATG 1 antibody, ATG1 antibody, ATG1 autophagy related 1 homolog antibody, ATG1A antibody, Autophagy related protein 1 homolog antibody, Autophagy-related protein 1 homolog antibody, FLJ38455 antibody, FLJ46475 antibody, hATG1 antibody, KIAA0722 antibody, Serine/threonine protein kinase ULK1 antibody, Serine/threonine protein kinase Unc51.1 antibody, Serine/threonine-protein kinase ULK1 antibody, ULK 1 antibody, ULK1 antibody, ULK1_HUMAN antibody, Unc 51 (C. elegans) like kinase 1 antibody, UNC 51 antibody, Unc 51 like kinase 1 antibody, Unc-51 like kinase 1 (C. elegans) antibody, Unc-51-like kinase 1 antibody, UNC51 antibody, UNC51, C. elegans, homolog of antibody, Unc51.1 antibody

UniProt: O75385

Pathways: Regulation of Cell Size, Autophagy