SLC5A8 antibody (AA 540-610) (Biotin)

Catalog No. ABIN7169961

The Rabbit Polyclonal anti-SLC5A8 antibody has been validated for ELISA. It is suitable to detect SLC5A8 in samples from Human.

Quick Overview for SLC5A8 antibody (AA 540-610) (Biotin) (ABIN7169961)

Target: SLC5A8 (Solute Carrier Family 5 (Iodide Transporter), Member 8 (SLC5A8))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC5A8 antibody is conjugated to Biotin

Application: ELISA

Product Details anti-SLC5A8 Antibody (Biotin)

Binding Specificity: AA 540-610

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Sodium-coupled monocarboxylate transporter 1 protein (540-610AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SLC5A8

Target: SLC5A8 (Solute Carrier Family 5 (Iodide Transporter), Member 8 (SLC5A8))

Alternative Name: SLC5A8

Background:

Background: Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons.

Aliases: AIT antibody, Apical iodide transporter antibody, Electrogenic sodium monocarboxylate cotransporter antibody, MGC125354 antibody, SC5A8_HUMAN antibody, SLC5A8 antibody, SMCT antibody, SMCT1 antibody, sodium coupled monocarboxylate transporter 1 antibody, Sodium iodide related cotransporter antibody, Sodium iodide-related cotransporter antibody, Sodium-coupled monocarboxylate transporter 1 antibody, solute carrier family 5 iodide transporter member 8 antibody, Solute carrier family 5 member 8 antibody

UniProt: Q8N695