TBC1D7 antibody (AA 1-293) (HRP)

Catalog No. ABIN7171661

This Rabbit Polyclonal antibody specifically detects TBC1D7 in ELISA. It exhibits reactivity toward Human.

Quick Overview for TBC1D7 antibody (AA 1-293) (HRP) (ABIN7171661)

Target: TBC1D7 (TBC1 Domain Family, Member 7 (TBC1D7))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TBC1D7 antibody is conjugated to HRP

Application: ELISA

Product Details anti-TBC1D7 Antibody (HRP)

Binding Specificity: AA 1-293

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human TBC1 domain family member 7 protein (1-293AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TBC1D7

Target: TBC1D7 (TBC1 Domain Family, Member 7 (TBC1D7))

Alternative Name: TBC1D7

Background:

Background: Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is unclear whether TBC1D7 acts as a GTPase-activating protein and additional studies are required to answer this question.

Aliases: TBC1D7 antibody, TBC7 antibody, HSPC239 antibody, TBC1 domain family member 7 antibody, Cell migration-inducing protein 23 antibody

UniProt: Q9P0N9