TCF3 antibody (AA 415-658)

Catalog No. ABIN7172509

Product Details anti-TCF3 Antibody

Target: TCF3 (Transcription Factor 3 (E2A Immunoglobulin Enhancer Binding Factors E12/E47) (TCF3))

Binding Specificity: AA 415-658

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TCF3 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Transcription factor E2-alpha protein (415-658AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TCF3

Target: TCF3 (Transcription Factor 3 (E2A Immunoglobulin Enhancer Binding Factors E12/E47) (TCF3))

Alternative Name: TCF3 (TCF3 Products)

Background:

Background: Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5\\\'-CANNTG-3\\\'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region.

Aliases: AGM8 antibody, bHLHb21 antibody, Class B basic helix-loop-helix protein 21 antibody, E12 antibody, E2A antibody, E2A immunoglobulin enhancer binding factors E12/E47 antibody, E47 antibody, Helix loop helix protein HE47 antibody, Immunoglobulin enhancer-binding factor E12/E47 antibody, Immunoglobulin transcription factor 1 antibody, ITF1 antibody, Kappa-E2-binding factor antibody, MGC129647 antibody, MGC129648 antibody, Negative vitamin D response element binding protein antibody, NOL1-TCF3 fusion antibody, TCF-3 antibody, Tcf3 antibody, TFE2_HUMAN antibody, transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) antibody, Transcription factor 3 antibody, transcription factor 3 variant 3 antibody, Transcription factor E2-alpha antibody, Transcription factor ITF-1 antibody, VDIR antibody, VDR interacting repressor antibody, vitamin D receptor-interacting repressor antibody

UniProt: P15923

Pathways: WNT Signaling, Stem Cell Maintenance, Regulation of Muscle Cell Differentiation, Production of Molecular Mediator of Immune Response