TEAD1 antibody (AA 135-215)

Catalog No. ABIN7172758

This anti-TEAD1 antibody is a Rabbit Polyclonal antibody detecting TEAD1 in WB, IHC, ELISA and IF. Suitable for Human.

Quick Overview for TEAD1 antibody (AA 135-215) (ABIN7172758)

Target: TEAD1 (TEA Domain Family Member 1 (SV40 Transcriptional Enhancer Factor) (TEAD1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TEAD1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-TEAD1 Antibody

Binding Specificity: AA 135-215

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Transcriptional enhancer factor TEF-1 protein (135-215AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:500, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TEAD1

Target: TEAD1 (TEA Domain Family Member 1 (SV40 Transcriptional Enhancer Factor) (TEAD1))

Alternative Name: TEAD1

Background:

Background: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC \\\'enhansons\\\' (5\\\'-GTGGAATGT-3\\\') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.

Aliases: AA antibody, Atrophia areata peripapillary chorioretinal degeneration antibody, NTEF 1 antibody, NTEF-1 antibody, NTEF1 antibody, Protein GT IIC antibody, Protein GT-IIC antibody, REF 1 antibody, REF1 antibody, SV40 transcriptional enhancer factor antibody, TCF 13 antibody, TCF-13 antibody, TCF13 antibody, TEA domain family member antibody, TEA domain family member 1 (SV40 transcriptional enhancer factor) antibody, TEA domain family member 1 antibody, TEAD 1 antibody, TEAD 1 protein antibody, TEAD-1 antibody, TEAD1 antibody, TEAD1 protein antibody, TEAD1_HUMAN antibody, TEF 1 antibody, TEF1 antibody, Transcription factor 13 (SV40 transcriptional enhancer factor) antibody, Transcription factor 13 antibody, Transcriptional enhancer factor 1 antibody, Transcriptional enhancer factor TEF-1 antibody, Transcriptional enhancer factor TEF1 antibody

UniProt: P28347

Pathways: Regulation of Lipid Metabolism by PPARalpha