TRPV1 antibody (AA 1-155)

Catalog No. ABIN7172875

This anti-TRPV1 antibody is a Rabbit Polyclonal antibody detecting TRPV1 in IHC, ELISA and IF. Suitable for Human.

Quick Overview for TRPV1 antibody (AA 1-155) (ABIN7172875)

Target: TRPV1 (Transient Receptor Potential Cation Channel, Subfamily V, Member 1 (TRPV1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRPV1 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-TRPV1 Antibody

Binding Specificity: AA 1-155

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Transient receptor potential cation channel subfamily V member 1 protein (1-155AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TRPV1

Target: TRPV1 (Transient Receptor Potential Cation Channel, Subfamily V, Member 1 (TRPV1))

Alternative Name: TRPV1

Background:

Background: Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions ( pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis.

Aliases: Capsaicin receptor antibody, DKFZp434K0220 antibody, osm 9 like TRP channel 1 antibody, Osm-9-like TRP channel 1 antibody, OTRPC1 antibody, Transient receptor potential cation channel subfamily V member 1 antibody, TRPV 1 antibody, Trpv1 antibody, TRPV1_HUMAN antibody, Vanilloid receptor 1 antibody, Vanilloid receptor subtype 1 antibody, VR 1 antibody, VR1 antibody

UniProt: Q8NER1

Pathways: Dicarboxylic Acid Transport