TMED1 antibody (AA 35-190)

Catalog No. ABIN7172974

This anti-TMED1 antibody is a Rabbit Polyclonal antibody detecting TMED1 in WB, ELISA and IHC. Suitable for Human.

Quick Overview for TMED1 antibody (AA 35-190) (ABIN7172974)

Target: TMED1 (Transmembrane Emp24 Protein Transport Domain Containing 1 (TMED1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TMED1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-TMED1 Antibody

Binding Specificity: AA 35-190

Cross-Reactivity: Human, Mouse

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Transmembrane emp24 domain-containing protein 10 protein (35-190AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TMED1

Target: TMED1 (Transmembrane Emp24 Protein Transport Domain Containing 1 (TMED1))

Alternative Name: TMED1

Background:

Background: Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED2 as their cargo receptor, the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1 (By similarity). In COPI vesicle-mediated retrograde transport involved in the biogenesis of COPI vesicles and vesicle coat recruitment. On Golgi membranes, acts as primary receptor for ARF1-GDP which is involved in COPI-vesicle formation. Increases coatomer-dependent GTPase-activating activity of ARFGAP2. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2LR1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Involved in trafficking of amyloid beta A4 protein and soluble APP-beta release (independent of modulation of gamma-secretase activity). As part of the presenilin-dependent gamma-secretase complex regulates gamma-cleavages of the amyloid beta A4 protein to yield amyloid-beta 40 (Abeta40). Involved in organization of the Golgi apparatus.

Aliases: 1110014C03Rik antibody, 21 kDa transmembrane trafficking protein antibody, 21 kDa transmembrane-trafficking protein antibody, MGC102351 antibody, p23 antibody, p24 family protein delta 1 antibody, p24 family protein delta-1 antibody, p24(DELTA) antibody, p24delta antibody, p24delta1 antibody, S31I125 antibody, S31III125 antibody, TMED 10 antibody, Tmed10 antibody, TMEDA_HUMAN antibody, Tmp 21 I antibody, Tmp 21 antibody, Tmp 21 I antibody, Tmp-21-I antibody, Transmembrane emp24 domain containing protein 10 antibody, Transmembrane emp24 domain-containing protein 10 antibody, Transmembrane emp24-like trafficking protein 10 (yeast) antibody, Transmembrane protein Tmp21 antibody, Transmembrane trafficking protein 21kD antibody

UniProt: P49755