TMEM59 antibody (AA 59-201)

Catalog No. ABIN7173245

This Rabbit Polyclonal antibody specifically detects TMEM59 in WB, ELISA and IF. It exhibits reactivity toward Human.

Quick Overview for TMEM59 antibody (AA 59-201) (ABIN7173245)

Target: TMEM59 (Transmembrane Protein 59 (TMEM59))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TMEM59 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-TMEM59 Antibody

Binding Specificity: AA 59-201

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Transmembrane protein 59 protein (59-201AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TMEM59

Target: TMEM59 (Transmembrane Protein 59 (TMEM59))

Alternative Name: TMEM59

Background:

Background: Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy (PubMed:27273576, PubMed:23376921). Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP (PubMed:20427278). Inhibits APP transport to the cell surface and further shedding (PubMed:20427278).

Aliases: C1orf8 antibody, HSPC001 antibody, Liver membrane-bound protein antibody, TMEM59 antibody, TMEM59 transmembrane protein 59 antibody, TMM59_HUMAN antibody, Transmembrane protein 59 antibody

UniProt: Q9BXS4