MIA3 antibody (AA 1447-1626)

Catalog No. ABIN7173309

The Rabbit Polyclonal anti-MIA3 antibody has been validated for ELISA. It is suitable to detect MIA3 in samples from Human.

Quick Overview for MIA3 antibody (AA 1447-1626) (ABIN7173309)

Target: MIA3 (Melanoma Inhibitory Activity Family, Member 3 (MIA3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MIA3 antibody is un-conjugated

Application: ELISA

Product Details anti-MIA3 Antibody

Binding Specificity: AA 1447-1626

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Transport and Golgi organization protein 1 homolog protein (1447-1626AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for MIA3

Target: MIA3 (Melanoma Inhibitory Activity Family, Member 3 (MIA3))

Alternative Name: MIA3

Background:

Background: Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum (PubMed:27138255, PubMed:19269366). Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and membrane-bound ER-resident complexes consisting of CTAGE5 and PREB/SEC12 to ERES (PubMed:28442536).

Aliases: ARNT antibody, C219 reactive peptide antibody, C219-reactive peptide antibody, D320 antibody, Melanoma inhibitory activity family, member 3 antibody, Melanoma inhibitory activity protein 3 antibody, Mia3 antibody, MIA3_HUMAN antibody, RP11-378J18.4 antibody, TANGO antibody, Transport and Golgi organization protein 1 antibody, UNQ6077 antibody

UniProt: Q5JRA6