TRADD antibody (AA 1-312) (Biotin)

Catalog No. ABIN7173905

This Rabbit Polyclonal antibody specifically detects TRADD in ELISA. It exhibits reactivity toward Human.

Quick Overview for TRADD antibody (AA 1-312) (Biotin) (ABIN7173905)

Target: TRADD (TNFRSF1A-Associated Via Death Domain (TRADD))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRADD antibody is conjugated to Biotin

Application: ELISA

Product Details anti-TRADD Antibody (Biotin)

Binding Specificity: AA 1-312

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Tumor necrosis factor receptor type 1-associated DEATH domain protein (1-312AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TRADD

Target: TRADD (TNFRSF1A-Associated Via Death Domain (TRADD))

Alternative Name: TRADD

Background:

Background: The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.

Aliases: 9130005N23Rik antibody, AA930854 antibody, TNFR1 associated DEATH domain protein antibody, TNFR1-associated DEATH domain protein antibody, TNFRSF1A associated via death domain antibody, TNFRSF1A-associated via death domain antibody, tradd antibody, TRADD_HUMAN antibody, Tumor necrosis factor receptor type 1 associated DEATH domain protein antibody, Tumor necrosis factor receptor type 1-associated DEATH domain protein antibody

UniProt: Q15628

Pathways: NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity, Hepatitis C