ATG7 antibody (AA 386-676) (HRP)

Catalog No. ABIN7174541

This Rabbit Polyclonal antibody specifically detects ATG7 in ELISA. It exhibits reactivity toward Human.

Quick Overview for ATG7 antibody (AA 386-676) (HRP) (ABIN7174541)

Target: ATG7 (ATG7 Autophagy Related 7 (ATG7))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATG7 antibody is conjugated to HRP

Application: ELISA

Product Details anti-ATG7 Antibody (HRP)

Binding Specificity: AA 386-676

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Ubiquitin-like modifier-activating enzyme ATG7 protein (386-676AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for ATG7

Target: ATG7 (ATG7 Autophagy Related 7 (ATG7))

Alternative Name: ATG7

Background:

Background: E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation.

Aliases: 1810013K23Rik antibody, Apg 7 antibody, APG7 autophagy 7 like antibody, APG7 autophagy 7-like (S. cerevisiae) antibody, APG7 like antibody, APG7, S. cerevisiae, homolog of antibody, APG7-like antibody, APG7L antibody, ATG 7 antibody, ATG12-activating enzyme E1 ATG7 antibody, ATG7 antibody, ATG7 autophagy related 7 homolog (S. cerevisiae) antibody, ATG7 autophagy related 7 homolog antibody, ATG7_HUMAN antibody, Atg7l antibody, Autophagy 7, S. cerevisiae, homolog of antibody, Autophagy related protein 7 antibody, Autophagy-related 7 (yeast) antibody, Autophagy-related protein 7 antibody, DKFZp434N0735 antibody, GSA 7 antibody, GSA7 antibody, hAGP7 antibody, Ubiquitin activating enzyme E1 like protein antibody, Ubiquitin-activating enzyme E1-like protein antibody, Ubiquitin-like modifier-activating enzyme ATG7 antibody

UniProt: O95352

Pathways: Response to Water Deprivation, Autophagy