VPS18 antibody (AA 298-515)

Catalog No. ABIN7175284

This anti-VPS18 antibody is a Rabbit Polyclonal antibody detecting VPS18 in ELISA and IHC. Suitable for Human.

Quick Overview for VPS18 antibody (AA 298-515) (ABIN7175284)

Target: VPS18 (Vacuolar Protein Sorting 18 Homolog (VPS18))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This VPS18 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Product Details anti-VPS18 Antibody

Binding Specificity: AA 298-515

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Vacuolar protein sorting-associated protein 18 homolog protein (298-515AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:200-1:500,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for VPS18

Target: VPS18 (Vacuolar Protein Sorting 18 Homolog (VPS18))

Alternative Name: VPS18

Background:

Background: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in dendrite development of Pukinje cells (By similarity).

Aliases: hVPS18 antibody, PEP3 antibody, Vacuolar protein sorting 18 antibody, Vacuolar protein sorting protein 18 antibody, Vacuolar protein sorting-associated protein 18 homolog antibody, vps18 antibody, VPS18_HUMAN antibody

UniProt: Q9P253

Pathways: Asymmetric Protein Localization