CACNA1B antibody (AA 2132-2339)

Catalog No. ABIN7175604

Product Details anti-CACNA1B Antibody

Target: CACNA1B (Calcium Channel, Voltage-Dependent, N Type, alpha 1B Subunit (CACNA1B))

Binding Specificity: AA 2132-2339

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CACNA1B antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Voltage-dependent N-type calcium channel subunit alpha-1B protein (2132-2339AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CACNA1B

Target: CACNA1B (Calcium Channel, Voltage-Dependent, N Type, alpha 1B Subunit (CACNA1B))

Alternative Name: CACNA1B (CACNA1B Products)

Background:

Background: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the \'high-voltage activated\' (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.

Aliases: CACNA1B antibody, CACH5 antibody, CACNL1A5 antibody, Voltage-dependent N-type calcium channel subunit alpha-1B antibody, Brain calcium channel III antibody, BIII antibody, Calcium channel antibody, L type antibody, alpha-1 polypeptide isoform 5 antibody, Voltage-gated calcium channel subunit alpha Cav2.2 antibody

UniProt: Q00975