P4HB antibody (AA 20-509)
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- Target See all P4HB Antibodies
- P4HB (Prolyl 4-Hydroxylase, beta Polypeptide (P4HB))
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Binding Specificity
- AA 20-509
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Reactivity
- Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This P4HB antibody is un-conjugated
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Application
- ELISA
- Cross-Reactivity
- Mouse
- Purification
- >95%, Protein G purified
- Immunogen
- Recombinant Mouse Protein disulfide-isomerase protein (20-509AA)
- Isotype
- IgG
- Top Product
- Discover our top product P4HB Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- P4HB (Prolyl 4-Hydroxylase, beta Polypeptide (P4HB))
- Alternative Name
- P4hb (P4HB Products)
- Background
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Background: This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP
Aliases: P4hb antibody, Pdia1Protein disulfide-isomerase antibody, PDI antibody, EC 5.3.4.1 antibody, Cellular thyroid hormone-binding protein antibody, Endoplasmic reticulum resident protein 59 antibody, ER protein 59 antibody, ERp59 antibody, Prolyl 4-hydroxylase subunit beta antibody, p55 antibody
- UniProt
- P09103
- Pathways
- Maintenance of Protein Location, Cell RedoxHomeostasis, Lipid Metabolism
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