Cobra Venom Factor,CVF (AA 733-984) antibody (HRP)
Quick Overview for Cobra Venom Factor,CVF (AA 733-984) antibody (HRP) (ABIN7178127)
Target
Reactivity
Host
Clonality
Conjugate
Application
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Binding Specificity
- AA 733-984
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Cross-Reactivity
- Cobra
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Purification
- >95%, Protein G purified
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Immunogen
- Recombinant Naja kaouthia Cobra venom factor protein (733-984AA)
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Isotype
- IgG
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anti-Cobra Venom Factor,CVF (AA 733-984) antibody
Reactivity: Cobra ELISA, WB Host: Rabbit Polyclonal unconjugated
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 -
Preservative
- ProClin
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Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- -20 °C,-80 °C
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Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Cobra Venom Factor,CVF
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Alternative Name
- Cobra venom factor
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Background
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Background: Complement-activating protein in cobra venom. It is a structural and functional analog of complement component C3b, the activated form of C3. It binds factor B (CFB), which is subsequently cleaved by factor D (CFD) to form the bimolecular complex CVF/Bb. CVF/Bb is a C3/C5 convertase that cleaves both complement components C3 and C5. Structurally, it resembles the C3b degradation product C3c, which is not able to form a C3/C5 convertase. Unlike C3b/Bb, CVF/Bb is a stable complex and completely resistant to the actions of complement regulatory factors H (CFH) and I (CFI). Therefore, CVF continuously activates complement resulting in the depletion of complement activity.
Aliases: antibody, Cobra venom factor antibody, CVF antibody, CVFk antibody, Complement C3 homolog) [Cleaved into: Cobra venom factor alpha chain, Cobra venom factor gamma chain, Cobra venom factor beta chain] antibody
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UniProt
- Q91132
Target
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