CD8 alpha antibody (PE-Cy5)

Catalog No. ABIN7178439

The Mouse Monoclonal anti-CD8 alpha antibody has been validated for FACS, IF and ELISA. It is suitable to detect CD8 alpha in samples from Human.

Quick Overview for CD8 alpha antibody (PE-Cy5) (ABIN7178439)

Target: CD8 alpha (CD8A) (CD8a Molecule (CD8A))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD8 alpha antibody is conjugated to PE-Cy5

Application: Flow Cytometry (FACS), Immunofluorescence (IF), ELISA

Product Details anti-CD8 alpha Antibody (PE-Cy5)

Purpose: CD8A Monoclonal Antibody,PE-Cy5 Conjugated

Purification: Affinity purified

Immunogen: Recombinant Protein

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Phosphate-buffered solution, pH 7.4, containing 0.09 % sodium azide and 0.2 % (w/v) BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CD8 alpha

Target: CD8 alpha (CD8A) (CD8a Molecule (CD8A))

Alternative Name: CD8A

Background:

Background: COV8 reacts with the 32 kDa a chain of CD8. This molecule is expressed on the T suppressor/cytotoxic cell population (which comprises about 1/3 of the peripheral blood T lymphocytes total population) and with most of thymocytes, as well as a subset of NK cells. CD8 expresses as either a heterodimer with the CD8b chain (CD8ab) or as a homodimer (CD8aa or CD8bb). CD8 acts as a co-receptor with MHC Class I restricted TCRs in antigen recognition. CD8 function is important for positive selection of MHC Class I restricted CD8+ T cells during T cell development.* Ratio of CD4 and CD8 is important for monitor of HIV infection.1. Engleman EG et al. (1981) J Exp Med 153: 193-198.2. Haynes, B et al. (1986) Leukocyte Typing II: Human T lymphocytes. New York: Sprimger-Verlag; 3-30.3. Parnes, JR. et al. (1989). Adv. Immunol. 44,256-311.4. Bikah G. et al. (1996). Science  274:1906.

Aliases: N/A

UniProt: P01732

Pathways: TCR Signaling