Simian Immunodeficiency Virus Vpx (SIV Vpx) (AA 1-112) antibody (Biotin)

Catalog No. ABIN7179348

The Rabbit Polyclonal anti- antibody has been validated for ELISA. It is suitable to detect in samples from Simian Immunodeficiency Virus (SIV).

Quick Overview for Simian Immunodeficiency Virus Vpx (SIV Vpx) (AA 1-112) antibody (Biotin) (ABIN7179348)

Target: Simian Immunodeficiency Virus Vpx (SIV Vpx)

Reactivity: Simian Immunodeficiency Virus (SIV)

Host: Rabbit

Clonality: Polyclonal

Conjugate: Biotin

Application: ELISA

Product Details

Binding Specificity: AA 1-112

Virus Strain: isolate K78

Purpose: vpx Antibody, Biotin conjugated

Cross-Reactivity: Simian Immunodeficiency Virus (SIV)

Purification: Protein G purified

Purity: >95 %

Immunogen: Recombinant Simian immunodeficiency virus Protein Vpx protein (1-112AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details

Target: Simian Immunodeficiency Virus Vpx (SIV Vpx)

Alternative Name: Simian immunodeficiency virus (isolate K78) (SIV-mac) (Simian immunodeficiency virus rhesus monkey) vpx

Background:

Background: Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription.

Aliases: vpx antibody, Protein Vpx antibody, Viral protein X antibody, X ORF protein antibody

UniProt: P11266