UBE2D2 antibody (C-Term)

Catalog No. ABIN7180280

This Rabbit Polyclonal antibody specifically detects UBE2D2 in WB and ELISA. It exhibits reactivity toward Human.

Quick Overview for UBE2D2 antibody (C-Term) (ABIN7180280)

Target: UBE2D2 (Ubiquitin-Conjugating Enzyme E2D 2 (UBE2D2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UBE2D2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-UBE2D2 Antibody

Binding Specificity: C-Term

Cross-Reactivity: Human

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from C-terminal of Human UBE2D2.

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:3000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for UBE2D2

Target: UBE2D2 (Ubiquitin-Conjugating Enzyme E2D 2 (UBE2D2))

Alternative Name: UBE2D2

Background:

Background: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3.

Jensen J.P., J. Biol. Chem. 270:30408-30414(1995).
Rolfe M., Proc. Natl. Acad. Sci. U.S.A. 92:3264-3268(1995).
Guinn B.-A., Biochem. Biophys. Res. Commun. 335:1293-1304(2005).

Aliases: E2(17)KB2 antibody, OTTHUMP00000223475 antibody, OTTHUMP00000223476 antibody, OTTHUMP00000223477 antibody, OTTHUMP00000223478 antibody, OTTHUMP00000224375 antibody, PUBC 1 antibody, PUBC1 antibody, UB2D2_HUMAN antibody, UBC 4 antibody, UBC 4/5 antibody, UBC4 antibody, UBC4/5 antibody, UBC4/5 homolog yeast antibody, UBCH 5B antibody, UBCH5B antibody, UBE2D2 antibody, Ubiquitin carrier protein antibody, Ubiquitin carrier protein D2 antibody, Ubiquitin conjugating enzyme E2 17 kDa 2 antibody, Ubiquitin conjugating enzyme E2 D2 antibody, Ubiquitin conjugating enzyme E2D 2 (homologous to yeast UBC4/5) antibody, Ubiquitin conjugating enzyme E2D 2 (UBC4/5 homolog yeast) antibody, Ubiquitin conjugating enzyme E2D 2 antibody, Ubiquitin protein ligase D2 antibody, Ubiquitin-conjugating enzyme E2 D2 antibody, Ubiquitin-conjugating enzyme E2(17)KB 2 antibody, Ubiquitin-conjugating enzyme E2-17 kDa 2 antibody, Ubiquitin-protein ligase D2 antibody

UniProt: P62837

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades