SENP3 antibody

Catalog No. ABIN7184127

The Rabbit Polyclonal anti-SENP3 antibody has been validated for WB, ELISA and IHC. It is suitable to detect SENP3 in samples from Human.

Quick Overview for SENP3 antibody (ABIN7184127)

Target: SENP3 (SUMO/sentrin Specific Peptidase 3 (SENP3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SENP3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-SENP3 Antibody

Cross-Reactivity: Human, Mouse

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from Internal of Human SENP3.

Isotype: IgG

Application Details

Application Notes: WB:1:500-1:3000, IHC:1:50-1:100,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SENP3

Target: SENP3 (SUMO/sentrin Specific Peptidase 3 (SENP3))

Alternative Name: SENP3

Background:

Background: Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1. Plays a role in the regulation of sumoylation status of ZNF148. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex, the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.

Yeh E.T.H., Gene 248:1-14(2000).
Choi S.J., Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
Wiemann S., Genome Res. 11:422-435(2001).

Aliases: SENP3 antibody, SENP3_HUMAN antibody, Sentrin / SUMO specific protease 3 antibody, Sentrin specific protease 3 antibody, Sentrin-specific protease 3 antibody, Sentrin/SUMO-specific protease SENP3 antibody, SMT3IP1 antibody, SSP3 antibody, SUMO 1 specific protease 3 antibody, SUMO-1-specific protease 3 antibody, SUMO1 specific protease 3 antibody, SUMO1/sentrin/SMT3 specific peptidase 3 antibody, SUSP3 antibody

UniProt: Q9H4L4