Histone Cluster 2 H4 Family Member a (HIST2H4A) Protein

Catalog No. ABIN7317723

This Recombinant protein is produced in Escherichia coli (E. coli).

Quick Overview for Histone Cluster 2 H4 Family Member a (HIST2H4A) Protein (ABIN7317723)

Target: Histone Cluster 2 H4 Family Member a (HIST2H4A)

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Purpose: Recombinant Human Histone H4/HIST2H4A Protein

Sequence: Met 1-Gly103

Characteristics: A DNA sequence encoding the human Histone H4 (NP_003539.1) (Met1-Gly103) was expressed.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile 2 mM β-ME in dd H2O, pH 6.0

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: Histone Cluster 2 H4 Family Member a (HIST2H4A)

Alternative Name: Histone H4/HIST2H4A

Background:

Background: Cyclin E1 is a member of the highly conserved cyclin family and belongs to the E-type cyclin that functions as a regulator of S phase entry and progression in mammalian cells. Cyclin E1 serves as regulatory subunits that bind, activate, and provide substrate for its associated cyclin-dependent kinase2 (CDK2), whose activity is essential for cell cycle G1 / S transition. Over expression of this encoding gene has been found in many tumors, which results in chromosome instability and by extension, induce tumorigenesis. This protein was also found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. In general, cyclin E1, as an activator of phospho-CDK2 (pCDK2), is important for cell cycle progression and is frequently overexpressed in cancer cells.

Synonym: FO108,H4,H4/A,H4/B,H4/C,H4/D,H4/E,H4/G,H4/H,H4/J,H4/K,H4/M,H4/N,H4F2,H4FA,H4FB,H4FC,H4FD,H4FE,H4FG,H4FH,H4FI,H4FJ,H4FK,H4FM,H4FN,HIST1H4A,HIST1H4B H4/I,HIST1H4C,HIST1H4D,HIST1H4E,HIST1H4F,HIST1H4H,HIST1H4I,HIST1H4J,HIST1H4K,HIST1H4L,HIST2H4,HIST2H4A

Molecular Weight: 11.4 kDa

NCBI Accession: NP_003539