Renin antibody (AA 331-406)

Catalog No. ABIN715436

The Rabbit Polyclonal anti-Renin antibody has been validated for WB, ELISA, IHC (p), IF (cc), IF (p) and IHC (fro). It is suitable to detect Renin in samples from Rat, Mouse and Dog. There are 4+ publications available.

Quick Overview for Renin antibody (AA 331-406) (ABIN715436)

Target: Renin (REN)

Reactivity: Rat, Mouse, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Renin antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-Renin Antibody

Binding Specificity: AA 331-406

Cross-Reactivity: Dog, Mouse, Rat

Predicted Reactivity: Human,Cow,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Renin

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-Renin antibody (ABIN715436)

Wu, Guo, Su, Wu, Li: "Biocharacterization of Heat Shock Protein 90 in Acetaminophen-Treated Livers Without Conspicuous Drug Induced Liver Injury." in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 43, Issue 4, pp. 1562-1570, (2017) (PubMed).

Soto, Melo, Marchesi, Lopes, Veras, Oliveira, Souza, de Castro, Furukawa, Saldiva, Heimann: "Exposure to fine particulate matter in the air alters placental structure and the renin-angiotensin system." in: PLoS ONE, Vol. 12, Issue 8, pp. e0183314, (2017) (PubMed).

Liu, Jiang, Zhang, Li, Li, Xie, Hu: "Pulmonary artery denervation improves pulmonary arterial hypertension induced right ventricular dysfunction by modulating the local renin-angiotensin-aldosterone system." in: BMC cardiovascular disorders, Vol. 16, Issue 1, pp. 192, (2016) (PubMed).

Wanka, Staar, Lutze, Peters, Hildebrandt, Beck, Bäumgen, Albers, Krieg, Zimmermann, Sczodrok, Schäfer, Hoffmann, Peters: "Anti-necrotic and cardioprotective effects of a cytosolic renin isoform under ischemia-related conditions." in: Journal of molecular medicine (Berlin, Germany), (2015) (PubMed).

Target Details for Renin

Target: Renin (REN)

Alternative Name: Renin

Background:

Synonyms: HNFJ2, Renin, Angiotensinogenase, REN

Background: Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.

Gene ID: 5972

UniProt: P00797

Pathways: ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour