ATF6B antibody (AA 370-450)

Catalog No. ABIN7213716

This anti-ATF6B antibody is a Rabbit Polyclonal antibody detecting ATF6B in WB, ELISA and IHC (p). Suitable for Human.

Quick Overview for ATF6B antibody (AA 370-450) (ABIN7213716)

Target: ATF6B (Activating Transcription Factor 6 beta (ATF6B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATF6B antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-ATF6B Antibody

Binding Specificity: AA 370-450

Purpose: ATF-6β Polyclonal Antibody

Specificity: ATF-6β Polyclonal Antibody detects endogenous levels of ATF-6β protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the Internal region of human ATF-6beta at AA range: 370-450

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:20000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for ATF6B

Target: ATF6B (Activating Transcription Factor 6 beta (ATF6B))

Alternative Name: ATF-6beta

Background: Rabbit Anti-ATF-6β Polyclonal Antibody,ATF6B, CREBL1, G13, Cyclic AMP-dependent transcription factor ATF-6 beta, cAMP-dependent transcription factor ATF-6 beta, Activating transcription factor 6 beta, ATF6-beta, Protein G13, cAMP response element-binding protein-related protein,The protein (activating transcription factor 6 beta) encoded by ATF6B is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum, however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for ATF6B.,Cyclic AMP-dependent transcription factor ATF-6 beta

Gene ID: 1388

UniProt: Q99941

Pathways: Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction