Aminoacylase 1 antibody

Catalog No. ABIN7227208

This anti-Aminoacylase 1 antibody is a Rabbit Polyclonal antibody detecting Aminoacylase 1 in WB and ELISA. Suitable for Human and Mouse.

Quick Overview for Aminoacylase 1 antibody (ABIN7227208)

Target: Aminoacylase 1 (ACY1)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Aminoacylase 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Aminoacylase 1 Antibody

Purpose: ACY1 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of ACY1 protein

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen

Immunogen: Synthesized peptide derived from part region of human ACY1 protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000-1:20000).

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for Aminoacylase 1

Target: Aminoacylase 1 (ACY1)

Alternative Name: ACY1

Background: Rabbit Anti-ACY1 Polyclonal Antibody,N-acyl-L-amino-acid amidohydrolase,ACY1 encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. ACY1 is located on chromosome 3p21. , a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in ACY1 cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between ACY1 and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID: 100526760. A related pseudogene has been identified on chromosome 18.,ACY1

Gene ID: 95

UniProt: Q03154