APLP1 antibody (AA 360-440)

Catalog No. ABIN7217668

This Rabbit Polyclonal antibody specifically detects APLP1 in WB, ELISA and IHC (p). It exhibits reactivity toward Human and Mouse.

Quick Overview for APLP1 antibody (AA 360-440) (ABIN7217668)

Target: APLP1 (Amyloid beta (A4) Precursor-Like Protein 1 (APLP1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APLP1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-APLP1 Antibody

Binding Specificity: AA 360-440

Purpose: APLP-1 Polyclonal Antibody

Specificity: APLP-1 Polyclonal Antibody detects endogenous levels of APLP-1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the Internal region of human APLP-1 at AA range: 360-440

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:10000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for APLP1

Target: APLP1 (Amyloid beta (A4) Precursor-Like Protein 1 (APLP1))

Alternative Name: APLP-1

Background: Rabbit Anti-APLP-1 Polyclonal Antibody,APLP1, Amyloid-like protein 1, APLP, APLP-1,APLP1 encodes a member of the highly conserved amyloid precursor protein gene family. The amyloid-like protein 1 is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described.,Amyloid-like protein 1

Gene ID: 333

UniProt: P51693

Pathways: cAMP Metabolic Process