DQB2 antibody

Catalog No. ABIN7228290

This Rabbit Polyclonal antibody specifically detects DQB2 in ELISA and WB. It exhibits reactivity toward Human.

Quick Overview for DQB2 antibody (ABIN7228290)

Target: DQB2 (DQB) (BoLa Class II Histocompatibility Antigen, DQB*0101 beta Chain (DQB))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DQB2 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-DQB2 Antibody

Purpose: DQB2 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of DQB2 protein

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen

Immunogen: Synthesized peptide derived from part region of human DQB2 protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000-1:20000).

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for DQB2

Target: DQB2 (DQB) (BoLa Class II Histocompatibility Antigen, DQB*0101 beta Chain (DQB))

Alternative Name: DQB2

Background: Rabbit Anti-DQB2 Polyclonal Antibody,HLA class II histocompatibility antigen, DQ beta 2 chain, HLA class II histocompatibility antigen, DX beta chain, MHC class II antigen DQB2,HLA-DQB2 belongs to the family of HLA class II beta chain paralogs. Class II molecules are heterodimers consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. They play a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: b lymphocytes, dendritic cells, macrophages). Polymorphisms in the alpha and beta chains specify the peptide binding specificity, and typing for these polymorphisms is routinely done for bone marrow transplantation. However this gene, HLA-DQB2, is not routinely typed, as it is not thought to have an effect on transplantation. There is conflicting evidence in the literature and public sequence databases for the protein-coding capacity of HLA-DQB2. Because there is evidence of transcription and an intact ORF, HLA-DQB2 is represented in Entrez Gene and in RefSeq as a protein-coding locus.,DQB2

Molecular Weight: observerd band 29kDa

Gene ID: 3120

UniProt: P05538