CASP14 antibody (AA 110-190)

Catalog No. ABIN7212434

This anti-CASP14 antibody is a Rabbit Polyclonal antibody detecting CASP14 in WB and ELISA. Suitable for Human.

Quick Overview for CASP14 antibody (AA 110-190) (ABIN7212434)

Target: CASP14 (Caspase 14, Apoptosis-Related Cysteine Peptidase (CASP14))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CASP14 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-CASP14 Antibody

Binding Specificity: AA 110-190

Purpose: Caspase-14 Polyclonal Antibody

Specificity: Caspase-14 Polyclonal Antibody detects endogenous levels of Caspase-14 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the Internal region of human Caspase-14 at AA range: 110-190

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:40000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for CASP14

Target: CASP14 (Caspase 14, Apoptosis-Related Cysteine Peptidase (CASP14))

Alternative Name: Caspase-14

Background: Rabbit Anti-Caspase-14 Polyclonal Antibody,CASP14, Caspase-14, CASP-14,CASP14 encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Caspase 14 has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of caspase 14 may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier.,Caspase-14

Molecular Weight: observerd band 27kDa

Gene ID: 23581

UniProt: P31944