CBX5 antibody (pSer92)

Catalog No. ABIN7220722

This anti-CBX5 antibody is a Rabbit Polyclonal antibody detecting CBX5 in ELISA and IHC (p). Suitable for Human.

Quick Overview for CBX5 antibody (pSer92) (ABIN7220722)

Target: CBX5 (Chromobox Homolog 5 (CBX5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CBX5 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-CBX5 Antibody

Binding Specificity: pSer92

Purpose: HP1α (phospho Ser92) Polyclonal Antibody

Specificity: Phospho-HP1α (S92) Polyclonal Antibody detects endogenous levels of HP1α protein only when phosphorylated at S92.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from human HP1alpha Phospho-Ser92

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC-P (1:100-1:300), ELISA (1:40000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for CBX5

Target: CBX5 (Chromobox Homolog 5 (CBX5))

Alternative Name: HP1alpha

Background: Rabbit Anti-HP1α (phospho Ser92) Polyclonal Antibody,CBX5, HP1A, Chromobox protein homolog 5, Antigen p25, Heterochromatin protein 1 homolog alpha, HP1 alpha,CBX5 encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The chromobox 5 is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified.,Chromobox protein homolog 5

Gene ID: 23468

UniProt: P45973