COX10 antibody (Internal Region)

Catalog No. ABIN7219600

The Rabbit Polyclonal anti-COX10 antibody has been validated for WB and ELISA. It is suitable to detect COX10 in samples from Human.

Quick Overview for COX10 antibody (Internal Region) (ABIN7219600)

Target: COX10 (Cytochrome C Oxidase Assembly Homolog 10 (COX10))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COX10 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-COX10 Antibody

Binding Specificity: Internal Region

Purpose: COX10 Polyclonal Antibody

Specificity: COX10 Polyclonal Antibody detects endogenous levels of COX10 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the Internal region of human COX10

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:10000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for COX10

Target: COX10 (Cytochrome C Oxidase Assembly Homolog 10 (COX10))

Alternative Name: COX10

Background: Rabbit Anti-COX10 Polyclonal Antibody,COX10, Protoheme IX farnesyltransferase, mitochondrial, Heme O synthase,Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. COX10 encodes heme A: farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. COX10, heme A: farnesyltransferase cytochrome c oxidase assembly factor is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion.,Protoheme IX farnesyltransferase mitochondrial

Molecular Weight: observerd band 49kDa

Gene ID: 1352

UniProt: Q12887