DNA Polymerase zeta (AA 200-280) antibody

Catalog No. ABIN7224004

The Rabbit Polyclonal anti-not_set antibody has been validated for ELISA and IHC (p). It is suitable to detect not_set in samples from Human and Mouse.

Quick Overview for DNA Polymerase zeta (AA 200-280) antibody (ABIN7224004)

Target: DNA Polymerase zeta

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details

Binding Specificity: AA 200-280

Purpose: DNA pol ζ Polyclonal Antibody

Specificity: DNA pol ζ Polyclonal Antibody detects endogenous levels of DNA pol ζ protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the N-terminal region of human DNA pol zeta at AA range: 200-280

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC-P (1:100-1:300), ELISA (1:20000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details

Target: DNA Polymerase zeta

Alternative Name: DNA pol zeta

Background: Rabbit Anti-DNA pol ζ Polyclonal Antibody,REV3L, POLZ, REV3, DNA polymerase zeta catalytic subunit, Protein reversionless 3-like, REV3-like, hREV3,DNA replication, recombination and repair, all of which are necessary for genomic stability, require the presence of exonucleases. In DNA replication, these enzymes are involved in the processing of Okazaki fragments, whereas in DNA repair, they function to excise damaged DNA fragments and correct recombinational mismatches. These exonucleases include the family of DNA polymerases. DNA pol α, β, δ, and e are involved in DNA replication and repair. DNA pol δ and DNA pol e are multisubunit enzymes, with DNA pol δ consisting of two subunits p125, which interacts with the sliding DNA clamp protein PCNA, and p50. The nuclear-encoded DNA pol γ is the only DNA polymerase required for the replication of the mitochondrial DNA. DNA pol Ω is ubiquitously expressed in various tissues and mediates the cellular mechanism of damage-induced mutagenesis. DNA pol is a DNA polymerase-helicase that binds ATP and is involved in the repair of interstrand crosslinks.,DNA polymerase zeta catalytic subunit

Gene ID: 5980

UniProt: O60673