Doublecortin antibody (pSer376)

Catalog No. ABIN7219988

This anti-Doublecortin antibody is a Rabbit Polyclonal antibody detecting Doublecortin in ELISA and IHC (p). Suitable for Human, Mouse and Rat.

Quick Overview for Doublecortin antibody (pSer376) (ABIN7219988)

Target: Doublecortin (DCX)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Doublecortin antibody is un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Doublecortin Antibody

Binding Specificity: pSer376

Purpose: Doublecortin (phospho Ser376) Polyclonal Antibody

Specificity: Phospho-Doublecortin (S376) Polyclonal Antibody detects endogenous levels of Doublecortin protein only when phosphorylated at S376.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from human Doublecortin Phospho-Ser376

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC-P (1:100-1:300), ELISA (1:5000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for Doublecortin

Target: Doublecortin (DCX)

Alternative Name: Doublecortin

Background: Rabbit Anti-Doublecortin (phospho Ser376) Polyclonal Antibody,DCX, DBCN, LISX, Neuronal migration protein doublecortin, Doublin, Lissencephalin-X, Lis-X,DCX encodes a member of the doublecortin family. Neuronal migration protein doublecortin encoded by DCX is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene.,Neuronal migration protein doublecortin

Gene ID: 1641

UniProt: O43602