GAB2 antibody (pSer623)

Catalog No. ABIN7226114

This anti-GAB2 antibody is a Rabbit Polyclonal antibody detecting GAB2 in WB, ELISA and IHC (p). Suitable for Human, Mouse and Rat.

Quick Overview for GAB2 antibody (pSer623) (ABIN7226114)

Target: GAB2 (GRB2-Associated Binding Protein 2 (GAB2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GAB2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-GAB2 Antibody

Binding Specificity: pSer623

Purpose: Gab 2 (phospho Ser623) Polyclonal Antibody

Specificity: Phospho-Gab 2 (S623) Polyclonal Antibody detects endogenous levels of Gab 2 protein only when phosphorylated at S623.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from human Gab 2 Phospho-Ser623

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:5000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for GAB2

Target: GAB2 (GRB2-Associated Binding Protein 2 (GAB2))

Alternative Name: Gab 2

Background: Rabbit Anti-Gab 2 (phospho Ser623) Polyclonal Antibody,GAB2, KIAA0571, GRB2-associated-binding protein 2, GRB2-associated binder 2, Growth factor receptor bound protein 2-associated protein 2, pp100,GAB2 (GRB2 associated binding protein 2) is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by GAB2 is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for GAB2.,GRB2-associated-binding protein 2

Molecular Weight: observerd band 80kDa

Gene ID: 9846

UniProt: Q9UQC2

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, BCR Signaling, Warburg Effect