HAND2 antibody

Catalog No. ABIN7228838

The Rabbit Polyclonal anti-HAND2 antibody has been validated for WB and ELISA. It is suitable to detect HAND2 in samples from Human, Mouse and Rat.

Quick Overview for HAND2 antibody (ABIN7228838)

Target: HAND2 (Heart and Neural Crest Derivatives Expressed 2 (HAND2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HAND2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-HAND2 Antibody

Purpose: HAND2 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of HAND2 protein

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen

Immunogen: Synthesized peptide derived from part region of human HAND2 protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000-1:20000).

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for HAND2

Target: HAND2 (Heart and Neural Crest Derivatives Expressed 2 (HAND2))

Alternative Name: HAND2

Background: Rabbit Anti-HAND2 Polyclonal Antibody,Heart- and neural crest derivatives-expressed protein 2, Class A basic helix-loop-helix protein 26, bHLHa26, Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2, dHAND,Heart And Neural Crest Derivatives Expressed 2 encoded by HAND2 belongs to the basic helix-loop-helix family of transcription factors. HAND2 product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, this transcription factor plays an important role in limb and branchial arch development. HAND2 (Heart And Neural Crest Derivatives Expressed 2) is a Protein Coding gene. Diseases associated with HAND2 include Saethre-Chotzen Syndrome and Split Hand-Foot Malformation. Among its related pathways are NFAT and Cardiac Hypertrophy and Heart Development.,HAND2

Molecular Weight: observerd band 23kDa

Gene ID: 9464

UniProt: P61296

Pathways: Tube Formation, Feeding Behaviour