IGF2R antibody (pSer2409)

Catalog No. ABIN7221718

This Rabbit Polyclonal antibody specifically detects IGF2R in WB, ELISA and IHC (p). It exhibits reactivity toward Human, Mouse and Monkey.

Quick Overview for IGF2R antibody (pSer2409) (ABIN7221718)

Target: IGF2R (Insulin-Like Growth Factor 2 Receptor (IGF2R))

Reactivity: Human, Mouse, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IGF2R antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-IGF2R Antibody

Binding Specificity: pSer2409

Purpose: IGF-IIR (phospho Ser2409) Polyclonal Antibody

Specificity: Phospho-IGF-IIR (S2409) Polyclonal Antibody detects endogenous levels of IGF-IIR protein only when phosphorylated at S2409.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from human IGF-IIR Phospho-Ser2409

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:10000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for IGF2R

Target: IGF2R (Insulin-Like Growth Factor 2 Receptor (IGF2R))

Alternative Name: IGF-IIR

Background: Rabbit Anti-IGF-IIR (phospho Ser2409) Polyclonal Antibody,IGF2R, MPRI, Cation-independent mannose-6-phosphate receptor, CI Man-6-P receptor, CI-MPR, M6PR, 300 kDa mannose 6-phosphate receptor, MPR 300, Insulin-like growth factor 2 receptor, Insulin-like growth factor II receptor, IGF-II receptor,IGF2R encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele, however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele.,Cation-independent mannose-6-phosphate receptor

Molecular Weight: observerd band 300kDa

Gene ID: 3482

UniProt: P11717