KCNQ2/3/4/5 (pThr217), (pThr223), (pThr246), (pThr251) antibody

Catalog No. ABIN7222018

The Rabbit Polyclonal anti-not_set antibody has been validated for ELISA and IHC (p). It is suitable to detect not_set in samples from Human, Mouse and Rat.

Quick Overview for KCNQ2/3/4/5 (pThr217), (pThr223), (pThr246), (pThr251) antibody (ABIN7222018)

Target: KCNQ2/3/4/5

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details

Binding Specificity: pThr217, pThr223, pThr246, pThr251

Purpose: KCNQ2/3/4/5 (phospho Thr217/246/223/251) Polyclonal Antibody

Specificity: Phospho-KCNQ2/3/4/5 (T217/246/223/251) Polyclonal Antibody detects endogenous levels of KCNQ2/3/4/5 protein only when phosphorylated at T217/246/223/251.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from human KCNQ2/3/4/5 Phospho-Thr217/246/223/251

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC-P (1:100-1:300), ELISA (1:20000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details

Target: KCNQ2/3/4/5

Background: Rabbit Anti-KCNQ2/3/4/5 (phospho Thr217/246/223/251) Polyclonal Antibody,KCNQ2, Potassium voltage-gated channel subfamily KQT member 2, KQT-like 2, Neuroblastoma-specific potassium channel subunit alpha KvLQT2, Voltage-gated potassium channel subunit Kv7.2, KCNQ3, Potassium voltage-gated channel subfamily KQT me,The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in KCNQ2 are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene.,Potassium voltage-gated channel subfamily KQT member 2

Gene ID: 3785, 3786, 9132