KIR5.1 antibody (pSer416)

Catalog No. ABIN7218824

The Rabbit Polyclonal anti-KIR5.1 antibody has been validated for WB, ELISA, IF and IHC (p). It is suitable to detect KIR5.1 in samples from Human, Rat and Mouse.

Quick Overview for KIR5.1 antibody (pSer416) (ABIN7218824)

Target: KIR5.1 (KCNJ16) (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 16 (KCNJ16))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KIR5.1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-KIR5.1 Antibody

Binding Specificity: pSer416

Purpose: KIR5.1 (phospho Ser416) Polyclonal Antibody

Specificity: Phospho-KIR5.1 (S416) Polyclonal Antibody detects endogenous levels of KIR5.1 protein only when phosphorylated at S416.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from human KIR5.1 Phospho-Ser416

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), IF (1:200-1:1000), ELISA (1:5000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for KIR5.1

Target: KIR5.1 (KCNJ16) (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 16 (KCNJ16))

Alternative Name: KIR5.1

Background: Rabbit Anti-KIR5.1 (phospho Ser416) Polyclonal Antibody,KCNJ16, Inward rectifier potassium channel 16, Inward rectifier K(+) channel Kir5.1, Potassium channel, inwardly rectifying subfamily J member 16,KCNJ16 (Potassium Voltage-Gated Channel Subfamily J Member 16) is a Protein Coding gene. Diseases associated with KCNJ16 include sesame syndrome and body dysmorphic disorder. Among its related pathways are Transmission across Chemical Synapses and Inwardly rectifying K+ channels. GO annotations related to this gene include inward rectifier potassium channel activity. An important paralog of this gene is KCNJ3. nward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium, as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance. In the kidney, together with KCNJ10, mediates basolateral K(+) recycling in distal tubules, this process is critical for Na(+) reabsorption at the tubules (PubMed: 24561201). he inward-rectifier potassium channel family (also known as 2-TM channels) include the strong inward-rectifier channels (Kir2. ), the G-protein-activated inward-rectifier channels (Kir3. ) and the ATP-sensitive channels (Kir6. ), which combine with sulphonylurea receptors.,Inward rectifier potassium channel 16

Molecular Weight: observerd band 48kDa