KIR5.1 antibody

Catalog No. ABIN7220004

This anti-KIR5.1 antibody is a Rabbit Polyclonal antibody detecting KIR5.1 in WB, ELISA, IF and IHC (p). Suitable for Human, Rat and Mouse.

Quick Overview for KIR5.1 antibody (ABIN7220004)

Target: KIR5.1 (KCNJ16) (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 16 (KCNJ16))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KIR5.1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-KIR5.1 Antibody

Purpose: KIR5.1 Polyclonal Antibody

Specificity: KIR5.1 Polyclonal Antibody detects endogenous levels of KIR5.1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from mouse KIR5.1 around the non-phosphorylation site of S416

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), IF (1:200-1:1000), ELISA (1:10000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for KIR5.1

Target: KIR5.1 (KCNJ16) (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 16 (KCNJ16))

Alternative Name: KIR5.1

Background: Rabbit Anti-KIR5.1 Polyclonal Antibody,KCNJ16, Inward rectifier potassium channel 16, Inward rectifier K(+) channel Kir5.1, Potassium channel, inwardly rectifying subfamily J member 16,Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which tends to allow potassium to flow into rather than out of a cell, can form heterodimers with two other inward-rectifier type potassium channels. It may function in fluid and pH balance regulation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2014]KCNJ16 (Potassium Voltage-Gated Channel Subfamily J Member 16) is a Protein Coding gene. Diseases associated with KCNJ16 include sesame syndrome and body dysmorphic disorder. Among its related pathways are Transmission across Chemical Synapses and Inwardly rectifying K+ channels. GO annotations related to this gene include inward rectifier potassium channel activity. An important paralog of this gene is KCNJ3. nward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium, as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance. In the kidney, together with KCNJ10, mediates basolateral K(+) recycling in distal tubules, this process is critical for Na(+) reabsorption at the tubules (PubMed: 24561201).,Inward rectifier potassium channel 16

Molecular Weight: observerd band 48kDa

Gene ID: 16517

UniProt: Q9NPI9