ARHGAP11A antibody (AA 440-520)

Catalog No. ABIN7226098

The Rabbit Polyclonal anti-ARHGAP11A antibody has been validated for ELISA and WB. It is suitable to detect ARHGAP11A in samples from Human.

Quick Overview for ARHGAP11A antibody (AA 440-520) (ABIN7226098)

Target: ARHGAP11A (rho GTPase Activating Protein 11A (ARHGAP11A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARHGAP11A antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-ARHGAP11A Antibody

Binding Specificity: AA 440-520

Purpose: ARHGAP11A Polyclonal Antibody

Specificity: ARHGAP11A Polyclonal Antibody detects endogenous levels of ARHGAP11A protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the Internal region of human ARHGAP11A at AA range: 440-520

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:40000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for ARHGAP11A

Target: ARHGAP11A (rho GTPase Activating Protein 11A (ARHGAP11A))

Alternative Name: ARHGAP11A

Background: Rabbit Anti-ARHGAP11A Polyclonal Antibody,ARHGAP11A, KIAA0013, Rho GTPase-activating protein 11A, Rho-type GTPase-activating protein 11A,GTPase-activating proteins (GAPs) accelerate the intrinsic rate of GTP hydrolysis of Ras-related proteins, resulting in downregulation of their active form. ARHGAP11A (Rho GTPase activating protein 11A), also known as KIAA0013 or MGC70740, is a 1,023 amino acid protein that contains one helical Rho-GAP domain and is encoded by a gene located on human chromosome 15. Defects in the gene encoding ARHGAP11A may cause mental retardation. Human chromosome 15 encodes over 700 genes and comprises nearly 3 % of the human genome. Angelman and Prader-Willi syndromes are associated with loss of function or deletion of genes in the 15q11-q13 region. In the case of Angelman syndrome, this loss is due to inactivity of the maternal 15q11-q13 encoded UBE3A gene in the brain by either chromosomal deletion or mutation. In cases of Prader-Willi syndrome, there is a partial or complete deletion of this region from the paternal copy of chromosome 15. Tay-Sachs disease is a lethal disorder associated with mutations of the HEXA gene, which is encoded by chromosome 15. Marfan syndrome is associated with chromosome 15 through the FBN1 gene.,Rho GTPase-activating protein 11A

Gene ID: 9824

UniProt: Q6P4F7