Sclerostin antibody (AA 130-210)

Catalog No. ABIN7222960

The Rabbit Polyclonal anti-Sclerostin antibody has been validated for WB and ELISA. It is suitable to detect Sclerostin in samples from Human.

Quick Overview for Sclerostin antibody (AA 130-210) (ABIN7222960)

Target: Sclerostin (SOST)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Sclerostin antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Sclerostin Antibody

Binding Specificity: AA 130-210

Purpose: Sclerostin Polyclonal Antibody

Specificity: Sclerostin Polyclonal Antibody detects endogenous levels of Sclerostin protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from the C-terminal region of human Sclerostin at AA range: 130-210

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:20000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for Sclerostin

Target: Sclerostin (SOST)

Alternative Name: Sclerostin

Background: Rabbit Anti-Sclerostin Polyclonal Antibody,SOST, Sclerostin,Sclerostin (SOST) is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in SOST are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of SOST, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.,Sclerostin

Molecular Weight: observerd band 26kDa

Gene ID: 50964

UniProt: Q9BQB4