Neuroligin 3 antibody (C-Term)

Catalog No. ABIN7233050

The Mouse Monoclonal anti-Neuroligin 3 antibody has been validated for WB, IHC and IF/ICC. It is suitable to detect Neuroligin 3 in samples from Rat.

Quick Overview for Neuroligin 3 antibody (C-Term) (ABIN7233050)

Target: Neuroligin 3 (NLGN3)

Reactivity: Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This Neuroligin 3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (fixed cells) (IF/ICC)

Clone: S110-29

Product Details anti-Neuroligin 3 Antibody

Binding Specificity: AA 730-848, C-Term

Purpose: Anti-Neuroligin-3 Mouse Monoclonal Antibody

Specificity: This antibody recognizes human, mouse and rat Neuroligin-3. It does not cross- react with Neuroligin-1, -2, or -4.

Cross-Reactivity: Human, Mouse, Rat

Immunogen: Fusion protein corresponding to aa 730-848 (intracellular C-terminus) of rat Neuroligin- 3. This sequence is 99

Isotype: IgG1

Application Details

Application Notes: Immunoblotting: use at 1-5 μg/mL. A band of ~110 kDa is detected.
Immunofluorescence: use at 10 μg/mL.
These are recommended concentrations.
Endusers should determine optimal concentrations for their application.

Restrictions: For Research Use only

Handling

Format: Liquid

Reconstitution: Dilute in PBS or medium that is identical to that used in the assay system.

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.4, 0.1 % sodium azide, 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: This product is stable for at least one (1) year at -20°C.

Target Details for Neuroligin 3

Target: Neuroligin 3 (NLGN3)

Alternative Name: Nlgn3

Background: Neuroligin-3,Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system. {PubMed:17897391}.,Neuroligin-3 is a neuronal cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. It plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. It may also promote the initial formation of synapses and play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system. Mutations in this gene may be associated with autism and Asperger syndrome. Multiple transcript variants encoding distinct isoforms have been identified for this gene.,Cell membrane, Single-pass type I membrane protein. Cell junction, synapse. Note=Detected at both glutamatergic and GABAergic synapses.,Gliotactin homolog

UniProt: Q62889

Pathways: Synaptic Membrane