C4A antibody (AA 1200-1446)

Catalog No. ABIN7266482

The Rabbit Polyclonal anti-C4A antibody has been validated for WB. It is suitable to detect C4A in samples from Human.

Quick Overview for C4A antibody (AA 1200-1446) (ABIN7266482)

Target: C4A (C4a) (Complement Fragment C4a (C4a))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C4A antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-C4A Antibody

Binding Specificity: AA 1200-1446

Purpose: Complement C4A Rabbit pAb

Sequence: LTLTKAPVDL LGVAHNNLMA MAQETGDNLY WGSVTGSQSN AVSPTPAPRN PSDPMPQAPA LWIETTAYAL LHLLLHEGKA EMADQASAWL TRQGSFQGGF RSTQDTVIAL DALSAYWIAS HTTEERGLNV TLSSTGRNGF KSHALQLNNR QIRGLEEELQ FSLGSKINVK VGGNSKGTLK VLRTYNVLDM KNTTCQDLQI EVTVKGHVEY TMEANEDYED YEYDELPAKD DPDAPLQPVT PLQLFEG

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1200-1446 of human Complement C4A (NP_009224.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for C4A

Target: C4A (C4a) (Complement Fragment C4a (C4a))

Alternative Name: C4A

Background: This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain is cleaved to release C4 anaphylatoxin, an antimicrobial peptide and a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene.,C4A,C4,C4A2,C4A3,C4A4,C4A6,C4AD,C4S,CO4,CPAMD2,RG,Immunology & Inflammation,Cell Intrinsic Innate Immunity Signaling Pathway,C4A

Molecular Weight: 187kDa/192kDa

Gene ID: 720

UniProt: P0C0L4

Pathways: Complement System